
Hopoo wanted to use this approach for the sequel, but the 2D graphic approach did not give them enough visual space to work with. The transition to 3D was partly inspired by fan art for the original game that showed the various objects the player collected shown on the character. When they started development on the sequel, Hopoo started with a 2D-based prototype with the player in control of one of the monsters in the first game, as to mix up the formula for the sequel. Risk of Rain 2 features several of the same playable characters, creatures, and items from the first game, but transitions the game from 2D to a 3D environment. In the metagame, players unlock access to new playable characters, items, and game modifiers by completing certain in-game achievements once unlocked, new characters called survivors, or modifiers are available to select from at the start of the game, or the new items can start appearing randomly in-game. However, the strength, difficulty, and numbers of aliens increase every few minutes, thus making the game harder the longer the players stay on any level. These collectible items offer a wide range of boosts to the players carrying them and provide both synergistic effects and the potential to stack their effects if multiple copies of the same items are acquired. Killing aliens gains experience and currency the currency can be used to open chests that randomly drop items on the level.

On each level the goal is to locate a teleporter, randomly located on the level once activated, the players must defend themselves from an onslaught of aliens, including bosses until the teleporter is fully active. Risk of Rain 2 follows a similar approach as the first title, in which one to four players must progress several levels while killing enemies. The game received generally positive reviews upon release. The game supports up to four players in online multiplayer. Over time, the game's difficulty increases, spawning more powerful and dangerous creatures. To survive, they navigate through various environments, killing monsters and looting chests to collect items that boost their offensive and defensive capabilities. Players control a survivor who is stranded on an alien planet.

A sequel to 2013's Risk of Rain, it was released in early access for Microsoft Windows, and Nintendo Switch, PlayStation 4 and Xbox One in 2019 before fully releasing on Augwith a release for Stadia coming a month later. Risk of Rain 2 is a roguelite third-person shooter developed by Hopoo Games and published by Gearbox Publishing.
